Magnetic Nanoparticles Used as Contrast Agents in MRI: Relaxometric Characterisation

Abstract

Magnetic resonance imaging (MRI) has developed at an exponential rate over the last decades, and the development of contrast agents to enhance the visualization of organs has followed the same trend. Meanwhile, magnetic nanoparticles that generate either “positive” or “negative” contrast in MRI have become one of the most important biomedical applications of nanotechnology. Indeed, superparamagnetic iron oxide nanoparticles, as negative contrast agents for T 2/T 2 * -weighted imaging, have found numerous applications in preclinical and clinical MRI (cell labeling, vascular contrast, lymph node imaging, liver contrast). In addition to this, paramagnetic and antiferromagnetic nanoparticles based on the elements Gd3+ and Mn2+ have mainly been exploited in vascular procedures and targeted imaging, for their capacity to enhance the MR signal of blood and of molecular signatures of endovascular disease. They are commonly referred to as “positive” contrast agents for T 1-weighted imaging.

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Title
Magnetic Nanoparticles Used as Contrast Agents in MRI: Relaxometric Characterisation
Book Title
Magnetic Characterization Techniques for Nanomaterials
Book DOI
10.1007/978-3-662-52780-1
Chapter DOI
10.1007/978-3-662-52780-1_15
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Editors
  • Challa S.S.R. Kumar Send Email (1)
  • Editor Affiliation
  • 1 Integrated Mesoscale Architectures for Sustainable Catalysis (IMASC), Rowland Institute of Science, Harvard University, Cambridge, Massachusetts, USA
  • Authors
  • Marc-André Fortin Send Email (2) (3)
  • Author Affiliation
  • 2 Laboratory for Biomaterials in Imaging, Axe médecine régénératrice, Centre de recherche du Centre hospitalier universitaire de Québec (CR-CHUQ), 2705, boul. Laurier (T1-61a), Quebec City, QC, G1V 4G2, Canada
  • 3 Département de génie des mines, de la métallurgie et des matériaux and Centre de recherche sur les matériaux avancés (CERMA), Université Laval, Quebec City, QC, G1V 0A6, Canada
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