High-Throughput Screening for the Production of Biomaterials: A New Tool for the Study of the Interactions Between Materials and Biological Species

Abstract

High-throughput screening (HTS) and combinatorial chemistry (CombiChem) methodologies refer to the fully automated, parallel synthesis and characterization of libraries of materials in a time- and cost-effective manner. Herein, we discuss the key principles of HTS, including the production tools and characterization techniques involved in the generation of different biologically relevant materials, ranging from polymer libraries to sol-gel derived hybrid materials. We describe applications of such libraries in the biomedical field as determined by the different properties of such biomaterials, and relate this to the importance of the interface between those materials and biological entities as a key element that controls the performance of the materials in specific applications.

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Title
High-Throughput Screening for the Production of Biomaterials: A New Tool for the Study of the Interactions Between Materials and Biological Species
Book Title
Handbook of Nanomaterials Properties
Book DOI
10.1007/978-3-642-31107-9
Chapter DOI
10.1007/978-3-642-31107-9_15
Part of
Volume
Editors
  • Bharat Bhushan Send Email (1)
  • Dan Luo Send Email (2)
  • Scott R. Schricker Send Email (3)
  • Wolfgang Sigmund Send Email (4)
  • Stefan Zauscher Send Email (5)
  • Editor Affiliation
  • 1 Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics, Ohio State University, Columbus, Ohio, USA
  • 2 Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA
  • 3 Division of Restorative, Prosthetic and Primary Care, The Ohio State University, College of Dentistry, Columbus, Ohio, USA
  • 4 Department of Materials Science and Engineering, University of Florida, Gainesville, Florida, USA
  • 5 Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA
  • Authors
  • Si Amar Dahoumane Send Email (6)
  • Blake-Joseph Helka Send Email (6)
  • Mathieu Artus Send Email (6)
  • Brandon Aubie Send Email (7)
  • John D. Brennan Send Email (6)
  • Author Affiliation
  • 6 Department of Chemistry and Chemical Biology, McMaster Univeristy, 1280 Main St. W., Hamilton, ON, Canada
  • 7 Biointerfaces Institute, McMaster University, 1280 Main St. W., Hamilton, ON, Canada
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