Modulating Protein Adhesion and Conformation with Block Copolymer Surfaces


Nanotechnology and nanostructured materials have a wide variety of applications in biotechnology and biomedicine. One of the more interesting applications of nanostructured materials is the control of the host response commonly referred to as biocompatibility. For many biomaterials, it is sufficient for host to have a minimal or virtually no response to be bioinert. Permanent implants such bone cements, dental implants, artificial joints, stents, and heart valves are all examples of materials that are considered bioinert or where it is important for them to be bioinert. In reality, no foreign material is completely bioinert, and this often leads to complications or failure of biomaterials. Designing materials that minimize the host response is very important and the focus of a great deal of research. However, in the past couple of decades, it has been the focus of biomaterial research to elicit a positive response, for instance, a bone implant that is osteoconductive and can induce healing. The field of tissue engineering is an example of biomaterials that are designed to induce regeneration that leads to functional tissues. Nanostructure has become one of the important methods to control biocompatibility and elicit an appropriate host response.

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Modulating Protein Adhesion and Conformation with Block Copolymer Surfaces
Book Title
Handbook of Nanomaterials Properties
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  • Bharat Bhushan Send Email (1)
  • Dan Luo Send Email (2)
  • Scott R. Schricker Send Email (3)
  • Wolfgang Sigmund Send Email (4)
  • Stefan Zauscher Send Email (5)
  • Editor Affiliation
  • 1 Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics, Ohio State University, Columbus, Ohio, USA
  • 2 Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA
  • 3 Division of Restorative, Prosthetic and Primary Care, The Ohio State University, College of Dentistry, Columbus, Ohio, USA
  • 4 Department of Materials Science and Engineering, University of Florida, Gainesville, Florida, USA
  • 5 Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA
  • Authors
  • Scott R. Schricker Send Email (6)
  • Manuel Palacio Send Email (7)
  • Bharat Bhushan Send Email (8)
  • Author Affiliation
  • 6 Section of Restorative, Prosthetic and Primary Care Dentistry, The Ohio State University, 305 W. 12th Ave, Columbus, OH, 43210, USA
  • 7 Western Digital, CA, USA
  • 8 Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics (NLBB), The Ohio State University, 201 West 19th Avenue, Columbus, OH, 43210, USA
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